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RNPA1000

RNPA1000

  • CAT Number: I003316
  • CAS Number: 359600-10-5
  • Molecular Formula: C23H18BrN3O3
  • Molecular Weight: 464.31
  • Purity: ≥95%
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<p style=/line-height:25px/>RNPA1000 is an attractive antimicrobial development candidate; RnpA inhibitor.<br>IC50 value:<br>Target: RnpA inhibitor<br>The antibiotic vancomycin and a novel Staphylococcus aureus RnpA inhibitor under pre-clinical development, RNPA1000, were included in these studies. Rheological testing characterized the workability of the glass polyalkenoate cement over a range of powder-to-liquid ratios and polyacrylic acid concentrations and revealed that the most suitable powder-to-liquid ratio was 2/1.25 with 40 wt% polyacrylic acid. Loading glass polyalkenoate cement with either 20-30% RNPA1000 or vancomycin prevented bacterial growth. However, longer incubations allowed for Staphylococcus aureus colonies to form near the vancomycin-infused cement, indicating that vancomycin may not be suitable for long-term biofilm inhibition in comparison to RNPA1000.</p>

Catalog Number I003316
CAS Number 359600-10-5
Molecular Formula

C23H18BrN3O3

Purity 95%
Target RnpA inhibitor
Solubility 10 mM in DMSO
Storage 3 years -20C powder
Reference

<p style=/line-height:25px/>
<br>[1]. Eidem TM, et al. Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus. J Biomater Appl. 2014 Apr;28(8):1235-46.
<br>[2]. Eidem TM, et al. Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing. Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28.
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