RN-1734

• CAT Number: I005635
• CAS Number: 946387-07-1
• Molecular Formula: C14H22Cl2N2O2S
• Molecular Weight: 353.302
• Purity: ≥95%
• Synonyms: RN1734; RN 1734
• Target: TRP Channel
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at +4C
• IC50: IC50 = 3.2 μM (rTRPV4)
• IUPAC Name: 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide
• InChI: InChI=1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
• InChIKey: IHYZMEAZAIFMTN-UHFFFAOYSA-N
• SMILES: CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(C=C(C=C1)Cl)Cl

RN-1734 (CAT: I005635) stands as a selective antagonist of the TRPV4 channel, a member of the transient receptor potential (TRP) channel family. Notably, RN-1734 demonstrates potent inhibitory effects on the activation of TRPV4 by the compound 4αPDD, effectively blocking its activity. Across different species, including human (hTRPV4), mouse (mTRPV4), and rat (rTRPV4), RN-1734 exhibits consistent and comparable inhibition with low micromolar IC50 values (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM). This selective antagonism of TRPV4 highlights RN-1734’s potential significance in pharmacological research, offering insights into the modulation of ion channels and the potential development of therapeutic interventions targeting TRPV4-related disorders.

Reference

[1]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. 


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