Rivaroxaban

• CAT Number: A000458
• CAS Number: 366789-02-8
• Molecular Formula: C₁₉H₁₈ClN₃O₅S
• Molecular Weight: 435.88
• Purity: ≥95%
• Target: Factor Xa
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
• InChIKey: KGFYHTZWPPHNLQ-AWEZNQCLSA-N
• SMILES: C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl

Rivaroxaban, also known as BAY 59-7939, is an oral anticoagulant invented and manufactured by Bayer; in a number of countries it is marketed as Xarelto. If approved by the United States FDA, it will be marketed by Ortho-McNeil Pharmaceutical. It is the first available orally active direct factor Xa inhibitor. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects lasts 8–12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible.

Reference

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