Riluzole

• CAT Number: A000389
• CAS Number: 1744-22-5
• Molecular Formula: C8H5F3N2OS
• Molecular Weight: 234.20
• Purity: ≥95%
• Synonyms: 1744-22-5; Rilutek; 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
• InChI: 1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
• InChIKey: FTALBRSUTCGOEG-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N

Riluzole (Cat No.: A000389) is a neuroprotective drug primarily used to treat amyotrophic lateral sclerosis (ALS). It works by inhibiting glutamate release, inactivating voltage-dependent sodium channels, and interfering with intracellular signaling pathways. These mechanisms help reduce excitotoxicity, a major contributor to neuron death in ALS. Riluzole modestly extends survival and delays the need for mechanical ventilation. It is administered orally and generally well-tolerated, though liver function monitoring is recommended. Research continues into its potential use in other neurodegenerative disorders.

Reference

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