Ribocil

• CAT Number: I001472
• CAS Number: 1381289-58-2
• Molecular Formula: C19H22N6OS
• Molecular Weight: 382.50
• Purity: ≥95%
• Synonyms: 2-[1-[[2-(methylamino)-5-pyrimidinyl]methyl]-3-piperidinyl]-6-(2-thienyl)-4(3H)-pyrimidinone
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 2-[1-[[2-(methylamino)pyrimidin-5-yl]methyl]piperidin-3-yl]-4-thiophen-2-yl-1H-pyrimidin-6-one
• InChI: InChI=1S/C19H22N6OS/c1-20-19-21-9-13(10-22-19)11-25-6-2-4-14(12-25)18-23-15(8-17(26)24-18)16-5-3-7-27-16/h3,5,7-10,14H,2,4,6,11-12H2,1H3,(H,20,21,22)(H,23,24,26)
• InChIKey: ZSXCVAIJFUEGJR-UHFFFAOYSA-N
• SMILES: CNC1=NC=C(C=N1)CN2CCCC(C2)C3=NC(=CC(=O)N3)C4=CC=CS4

Ribocil（Cat No.:I001472）is a selective inhibitor of the ribose-binding protein (RBP) involved in the ribose utilization pathway of Pseudomonas aeruginosa. This compound has shown promise in inhibiting the growth of biofilm-forming bacteria, particularly in antibiotic-resistant strains. By targeting the ribose-binding protein, Ribocil effectively disrupts the bacterium’s energy production, making it a valuable tool in combating infections caused by multidrug-resistant organisms. This inhibitor can contribute to the development of novel therapeutic strategies aimed at overcoming bacterial resistance and enhancing the efficacy of existing antibiotics in clinical settings.

Reference

[1]. Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.