CONTACT US
Home > Inhibitors/Agonists>Heterocyclic Building Blocks> > RG 13022
RG 13022

RG 13022

  • CAT Number: I009020
  • CAS Number: 136831-48-6
  • Molecular Formula: C16H14N2O2
  • Molecular Weight: 266.3
  • Purity: ≥95%
Inquiry Now

RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 µM in HT-22 cells. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs.

Catalog Number I009020
CAS Number 136831-48-6
Synonyms

RG 13022; RG13022; RG-13022.Tyrphostin RG 13022;3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-

Molecular Formula

C16H14N2O2

Purity 95%
Target EGF Receptor Inhibitor
Solubility Soluble in DMSO
Storage 0 - 4 °C for short term, or -20 °C for long term
InChI InChI=1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3/b14-8-
InChIKey DBGZNJVTHYFQJI-ZSOIEALJSA-N
SMILES N#C/C(C1=CC=CN=C1)=C/C2=CC=C(OC)C(OC)=C2
Reference

</br>1:Komatsu N, Maekawa T, Takeuchi S, Takahashi S. Epidermal growth factor and transforming growth factor-alpha stimulate the proliferation of mouse uterine stromal cells. Zoolog Sci. 2003 May;20(5):639-45. PubMed PMID: 12777835.</br>2: Levitzki A. Tyrosine kinases as targets for cancer therapy. Eur J Cancer. 2002 Sep;38 Suppl 5:S11-8. Review. PubMed PMID: 12528768.</br>3: Takahashi S, Sharma S, Oomizu S, Honda J, Takeuchi S. Intrapituitary regulatory system of mammotrophs in the mouse. Arch Physiol Biochem. 2002 Apr;110(1-2):34-41. PubMed PMID: 11935398.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!