Resveratrol

• CAT Number: A000646
• CAS Number: 501-36-0
• Molecular Formula: C14H12O3
• Molecular Weight: 228.24
• Purity: ≥95%
• Target: Sirtuin
• Solubility: >9.7mg/mL in DMSO
• Storage: <label class=
• IUPAC Name: 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
• InChI: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
• InChIKey: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
• SMILES: C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O

Resveratrol (CAS 501-36-0) is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner.

Overview of Clinical Research

Resveratrol is an antioxidant and a ribonucleotide reductase inhibitor as well as a SIRT1 protein stimulant. It has been granted for its orphan drug status in MELAS syndrome.

Reference

1: Granados-Soto V. Pleiotropic effects of resveratrol. Drug News Perspect. 2003 Jun;16(5):299-307. Review. PubMed PMID: 12942161.
2: Kimura Y. Pharmacological studies on resveratrol. Methods Find Exp Clin Pharmacol. 2003 May;25(4):297-310. Review. PubMed PMID: 12808475.
3: Ratan HL, Steward WP, Gescher AJ, Mellon JK. Resveratrol–a prostate cancer chemopreventive agent? Urol Oncol. 2002 Nov-Dec;7(6):223-7. Review. PubMed PMID: 12504842.
4: Ignatowicz E, Baer-Dubowska W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol J Pharmacol. 2001 Nov-Dec;53(6):557-69. Review. PubMed PMID: 11985329.