Resveratrol

  • CAT Number: A000646
  • CAS Number: 501-36-0
  • Molecular Formula: C14H12O3
  • Molecular Weight: 228.24
  • Purity: ≥95%
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Resveratrol (CAS 501-36-0) is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner.

Catalog Number A000646
CAS Number 501-36-0
Synonyms

trans-resveratrol; 3,4′,5-Trihydroxystilbene

Molecular Formula

C14H12O3

Purity 95%
Target Sirtuin
Solubility >9.7mg/mL in DMSO
Storage <label class=
Overview of Clinical Research

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Resveratrol is an a<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">ntioxidant and a ribonucleotide reductase inhibitor as well as a SIRT1 protein stimulant. It has been granted for its orphan drug status in MELAS syndrome.</span></span></span></span>

IUPAC Name 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
InChIKey LUKBXSAWLPMMSZ-OWOJBTEDSA-N
SMILES C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
Reference

1: Granados-Soto V. Pleiotropic effects of resveratrol. Drug News Perspect. 2003 Jun;16(5):299-307. Review. PubMed PMID: 12942161.<br />
2: Kimura Y. Pharmacological studies on resveratrol. Methods Find Exp Clin Pharmacol. 2003 May;25(4):297-310. Review. PubMed PMID: 12808475.<br />
3: Ratan HL, Steward WP, Gescher AJ, Mellon JK. Resveratrol–a prostate cancer chemopreventive agent? Urol Oncol. 2002 Nov-Dec;7(6):223-7. Review. PubMed PMID: 12504842.<br />
4: Ignatowicz E, Baer-Dubowska W. Resveratrol, a natural chemopreventive agent against degenerative diseases. Pol J Pharmacol. 2001 Nov-Dec;53(6):557-69. Review. PubMed PMID: 11985329.

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