Resistomycin

• CAT Number: R004317
• CAS Number: 20004-62-0
• Molecular Formula: C22H16O6
• Molecular Weight: 376.364
• Purity: ≥95%
• Synonyms: 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione
• Target: Antibiotic
• Solubility: Soluble in DMSO
• Storage: -20°C
• InChI: InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,23-26H,1-3H3
• InChIKey: ABLACSIRCKEUOB-UHFFFAOYSA-N
• SMILES: CC1=CC(=C2C3=C4C(=CC(=C13)O)C(C(=O)C5=C(C=C(C(=C45)C2=O)O)O)(C)C)O

Resistomycin(CAT: R004317) is a naturally occurring antibiotic produced by Streptomyces species. Its mode of action involves inhibiting bacterial RNA synthesis, making it a potent antibacterial agent. Resistomycin has shown activity against various Gram-positive and some Gram-negative bacteria, making it of interest in medical research and drug development. Resistomycin finds applications in microbiological studies, as well as in the discovery of new antibiotics and other pharmaceutical compounds.

Reference

Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Shiono Y. et al. Z Naturforsch. [C] 2002, 57, 923.3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity. Roggo B.E. J. Antibiot. 1994, 47, 136.Molecular structure of heliomycin, an inhibitor of RNA synthesis. Arora S.K. J. Antibiot. 1985, 38, 113