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Resiniferatoxin

Resiniferatoxin

  • CAT Number: R022222
  • CAS Number: 57444-62-9
  • Molecular Formula: C37H40O9
  • Molecular Weight: 628.7
  • Purity: 98%
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<p>
Resiniferatoxin (RTX; CAS 57444-62-9),a potent agonist of vanilloid TRPV1 receptors,&nbsp;is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in sensory neurons involved in transmission of pain signals.</p>

Catalog Number R022222
CAS Number 57444-62-9
Molecular Formula

C37H40O9

Purity 98
Target TRP Channel
Solubility Soluble in DMSO > 10 mM
Storage Desiccate at -20C
Overview of Clinical Research

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Resiniferatoxin is a&nbsp;<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">TRPV1 receptor agonist. It has been granted for the orphan drug status in cancer pain.&nbsp;</span></span></span></span>

Analysis method HPLC
IUPAC Name [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate
InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1
InChIKey DSDNAKHZNJAGHN-IHCAYWNCSA-N
SMILES CC1CC2(C3C4C1(C5C=C(C(=O)C5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)OC(O3)(O2)CC7=CC=CC=C7)C(=C)C
Reference

<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Szolcsanyi, J. A. N. O. S., et al. &quot;Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Journal of Pharmacology and Experimental Therapeutics</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;255.2 (1990): 923-928.<br />
2.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Szallasi, Arpad, and Peter M. Blumberg. &quot;Resiniferatoxin.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Methods in neurosciences</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">. Vol. 8. Academic Press, 1992. 368-380.</span></span></span></span>

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