Resibufogenin

• CAT Number: I003615
• CAS Number: 465-39-4
• Molecular Formula: C24H32O4
• Molecular Weight: 384.5
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 5-[(1R,2S,4R,6R,7R,10S,11S,14S,16R)-14-hydroxy-7,11-dimethyl-3-oxapentacyclo[8.8.0.02,4.02,7.011,16]octadecan-6-yl]pyran-2-one
• InChI: InChI=1S/C24H32O4/c1-22-9-7-16(25)11-15(22)4-5-18-17(22)8-10-23(2)19(12-20-24(18,23)28-20)14-3-6-21(26)27-13-14/h3,6,13,15-20,25H,4-5,7-12H2,1-2H3/t15-,16+,17+,18-,19-,20-,22+,23-,24-/m1/s1
• InChIKey: ATLJNLYIJOCWJE-CWMZOUAVSA-N
• SMILES: C[C@]12CC[C@@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@]35[C@H](O5)C[C@@H]4C6=COC(=O)C=C6)C)O

Resibufogenin (Cat.No:I003615) is a naturally occurring bufadienolide compound found in plants of the Bufonidae family. It exhibits diverse pharmacological properties, including antitumor, antiviral, and anti-inflammatory activities. Resibufogenin has been studied for its potential in cancer therapy and may offer opportunities for the development of new therapeutic agents.

Reference

1:Liver-targeting Resibufogenin-loaded poly(lactic-co-glycolic acid)-D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy. Chu Q, Xu H, Gao M, Guan X, Liu H, Deng S, Huo X, Liu K, Tian Y, Ma X.Int J Nanomedicine. 2016 Jan 27;11:449-63. doi: 10.2147/IJN.S93541. eCollection 2016. PMID: 26869788 Free PMC Article2:Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells. Ichikawa M, Sowa Y, Iizumi Y, Aono Y, Sakai T.PLoS One. 2015 Jun 29;10(6):e0129851. doi: 10.1371/journal.pone.0129851. eCollection 2015. PMID: 26121043 Free PMC Article3:Characterization of phase I metabolism of resibufogenin and evaluation of the metabolic effects on its antitumor activity and toxicity. Ning J, Yu ZL, Hu LH, Wang C, Huo XK, Deng S, Hou J, Wu JJ, Ge GB, Ma XC, Yang L.Drug Metab Dispos. 2015 Mar;43(3):299-308. doi: 10.1124/dmd.114.060996. Epub 2014 Dec 11. PMID: 25504504 Free Article4:Resibufogenin and cinobufagin activate central neurons through an ouabain-like action. Wang ZJ, Sun L, Heinbockel T.PLoS One. 2014 Nov 24;9(11):e113272. doi: 10.1371/journal.pone.0113272. eCollection 2014. PMID: 25420080 Free PMC Article5:Biotransformation of resibufogenin by Actinomucor elegans. Mou LY, Xin XL, Chen L, Dong PP, Lan R, Su DH, Huang J, Wang JH, Zhan LB.J Asian Nat Prod Res. 2014;16(6):623-8. doi: 10.1080/10286020.2014.921911. Epub 2014 Jun 9. PMID: 24911667 6:Microbial transformation of resibufogenin by Curvularia lunata AS 3.4381. Xin XL, Sun JH, Wang XB, Xi RG, Wang G, Lan R, Su DH, Li H, Huo XK, Wang C.J Asian Nat Prod Res. 2014;16(3):290-5. doi: 10.1080/10286020.2013.878332. PMID: 24456251 7:[Determination of cinobufagin and resibufogenin in liver tissue by HPLC-MS/MS]. Wang W, Liu MD, Yan YY, Ye Y, Zhao JH, Xiong H, Xiao M, Liao LC.Fa Yi Xue Za Zhi. 2013 Aug;29(4):268-72. Chinese. PMID: 24350542 8:[Determination of protein binding rates of cinobufagin and resibufogenin with different plasmas by HPLC]. Cao W, Chen Y, Yuan L, He JJ.Yao Xue Xue Bao. 2012 Sep;47(9):1200-4. Chinese. PMID: 23227551 9:Isolation and identification of phase I metabolites of resibufogenin in rats. Zhu ZT, Deng S, Liu D, Zhang BJ, Sun HZ, Tian Y, Wang CY, Wang L, Ma XC.Xenobiotica. 2013 May;43(5):479-85. doi: 10.3109/00498254.2012.728728. Epub 2012 Nov 15. PMID: 23153055 10:Marinobufagenin predicts and resibufogenin prevents preeclampsia: a review of the evidence. Puschett JB.Am J Perinatol. 2012 Nov;29(10):777-85. doi: 10.1055/s-0032-1316447. Epub 2012 Jul 16. Review. PMID: 22814872