ReN-1869 hydrochloride

• CAT Number: I013581
• CAS Number: 170149-76-5
• Molecular Formula: C₂₄H₂₈ClNO₂
• Molecular Weight: 397.94
• Purity: ≥95%
• Target: Histamine Receptor
• Solubility: DMSO
• IUPAC Name: (3R)-1-[3-(5,6-dihydrodibenzo[1,2-a:1//',2//'-e][7]annulen-11-ylidene)propyl]piperidine-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C24H27NO2.ClH/c26-24(27)20-9-5-15-25(17-20)16-6-12-23-21-10-3-1-7-18(21)13-14-19-8-2-4-11-22(19)23;/h1-4,7-8,10-12,20H,5-6,9,13-17H2,(H,26,27);1H/t20-;/m1./s1
• InChIKey: OJCOPCYFLFDPTD-VEIFNGETSA-N
• SMILES: C1CC(CN(C1)CCC=C2C3=CC=CC=C3CCC4=CC=CC=C42)C(=O)O.Cl

ReN 1869 hydrochloride is a novel, selective histamine H1 receptor antagonist, which demonstrates affinity to the histamine H1 receptor (guinea pig brain) with Ki of 0.19±0.04 μM and the non-selective σ site (guinea pig brain) with Ki of 0.45 μM.

Reference

[1]. Olsen UB, et al. ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57.