REN-1189

• CAT Number: I009006
• CAS Number: 183619-38-7
• Molecular Formula: C13H18N2O2
• Molecular Weight: 234.299
• Purity: ≥95%
• Target: TNF-α
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 4-acetamido-N-tert-butylbenzamide
• InChI: InChI=1S/C13H18N2O2/c1-9(16)14-11-7-5-10(6-8-11)12(17)15-13(2,3)4/h5-8H,1-4H3,(H,14,16)(H,15,17)
• InChIKey: DJKNRCWSXSZACF-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC(C)(C)C

REN-1189 (Cat.No:I009006) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.

Reference

1: Müller T. CPI-1189. Centaur. Curr Opin Investig Drugs. 2002 Dec;3(12):1763-7. Review. PubMed PMID: 12528314.2: Clifford DB, McArthur JC, Schifitto G, Kieburtz K, McDermott MP, Letendre S, Cohen BA, Marder K, Ellis RJ, Marra CM; Neurologic AIDS Research Consortium.. A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology. 2002 Nov 26;59(10):1568-73. PubMed PMID: 12451199.3: Bjugstad KB, Flitter WD, Garland WA, Philpot RM, Kirstein CL, Arendash GW. CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex. J Neurovirol. 2000 Dec;6(6):478-91. PubMed PMID: 11175320.