For research use only. Not for therapeutic Use.
(rel)-Tivantinib(CAT: I040449) is a potent and selective small-molecule inhibitor primarily targeting the receptor tyrosine kinase c-MET, a key regulator of tumor growth, survival, and metastasis. In addition to its c-MET inhibition, (rel)-Tivantinib also acts on two novel intracellular targets—GSK3α and GSK3β—critical components in non-small cell lung cancer (NSCLC) signaling pathways. Through dual inhibition, it disrupts cancer cell proliferation and survival mechanisms, making it a valuable candidate for therapeutic development. (rel)-Tivantinib is widely studied in oncology research for its multi-targeted approach, offering promise in overcoming resistance and enhancing efficacy in c-MET-driven and GSK3-mediated cancers.
| CAS Number | 905853-99-8 |
| Synonyms | (3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione |
| Molecular Formula | C23H19N3O2 |
| Purity | ≥95% |
| IUPAC Name | (3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione |
| InChI | InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1 |
| InChIKey | UCEQXRCJXIVODC-PMACEKPBSA-N |
| SMILES | C1CC2=C3C(=CC=C2)C(=CN3C1)C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
