Ranolazine-d8

• CAT Number: R072161
• CAS Number: 1092804-88-0
• Molecular Formula: C24H25D8N3O4
• Molecular Weight: 435.59
• Purity: ≥95%
• Synonyms: N-(2,6-dimethylphenyl)-2-[2,2,3,3,5,5,6,6-octadeuterio-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
• InChI: InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)/i11D2,12D2,13D2,14D2
• InChIKey: XKLMZUWKNUAPSZ-FUEQIQQISA-N
• SMILES: [2H]C1(C(N(C(C(N1CC(COC2=CC=CC=C2OC)O)([2H])[2H])([2H])[2H])CC(=O)NC3=C(C=CC=C3C)C)([2H])[2H])[2H]

Ranolazine-d8（Cat No.:R072161）is a deuterium-labeled form of ranolazine, an anti-anginal agent used to treat chronic angina by improving myocardial efficiency without significantly affecting heart rate or blood pressure. Incorporating eight deuterium atoms, it serves as a stable isotope for use in mass spectrometry-based pharmacokinetic and metabolic studies. Ranolazine-d8 retains the pharmacological activity of the parent compound, inhibiting the late sodium current (INaL) in cardiac cells, which helps reduce intracellular calcium overload. It is widely used in bioanalytical research to monitor drug absorption, distribution, metabolism, and excretion with high precision and minimal interference.