Ramipril

• CAT Number: A000717
• CAS Number: 87333-19-5
• Molecular Formula: C23H32N2O5
• Molecular Weight: 416.5
• Purity: ≥95%
• Target: ACE
• Solubility: >17.6mg/mL in DMSO
• Storage: <label class=
• IUPAC Name: (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
• InChI: InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
• InChIKey: HDACQVRGBOVJII-JBDAPHQKSA-N
• SMILES: O=C([C@H](C)N[C@H](C(OCC)=O)CCC1=CC=CC=C1)N2[C@]3([H])[C@](CCC3)([H])C[C@H]2C(O)=O

Ramipril (Cat No.:A000717) is an antihypertensive agent, an angiotensin-converting enzyme (ACE) inhibitor that converts to an active diacid metabolite. It is used for renal and mild, moderate and severe essential hypertension, as well as moderate and malignant congestive heart failure.

Overview of Clinical Research

Ramipril is an ACE inhibitor. The Phase-II clinical trials in COVID-2019 infections starts in USA (PO) (NCT04366050).

Reference

1: Omboni S, Malacco E, Mallion JM, Fabrizzi P, Volpe M. Olmesartan vs. ramipril in elderly hypertensive patients: review of data from two published randomized, double-blind studies. High Blood Press Cardiovasc Prev. 2014 Mar;21(1):1-19. doi: 10.1007/s40292-013-0037-9. Epub 2014 Jan 17. Review. PubMed PMID: 24435506.
2: Vuong AD, Annis LG. Ramipril for the prevention and treatment of cardiovascular disease. Ann Pharmacother. 2003 Mar;37(3):412-9. Review. PubMed PMID: 12639174.
3: Frampton JE, Peters DH. Ramipril. An updated review of its therapeutic use in essential hypertension and heart failure. Drugs. 1995 Mar;49(3):440-66. Review. PubMed PMID: 7774515.
4: Meisel S, Shamiss A, Rosenthal T. Clinical pharmacokinetics of ramipril. Clin Pharmacokinet. 1994 Jan;26(1):7-15. Review. PubMed PMID: 8137599.