Kaempferide

• CAT Number: I003728
• CAS Number: 491-54-3
• Molecular Formula: C16H12O6
• Molecular Weight: 300.26
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one
• InChI: InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3
• InChIKey: SQFSKOYWJBQGKQ-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

Kaempferide (Cat.No:I003728) is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4/’-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

Reference

1:Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats. Wang S, Xu H, Xin Y, Li M, Fu W, Wang Y, Lu Z, Yu X, Sui D.Eur J Pharmacol. 2016 Oct 5;788:335-42. doi: 10.1016/j.ejphar.2016.08.007. Epub 2016 Aug 4. PMID: 27497882 2:Synthesis of kaempferide Mannich base derivatives and their antiproliferative activity on three human cancer cell lines. Nguyen VS, Shi L, Luan FQ, Wang QA.Acta Biochim Pol. 2015;62(3):547-52. doi: 10.18388/abp.2015_992. Epub 2015 Sep 8. PMID: 26345098 Free Article3:Kaempferide-7-O-(4/-O-acetylrhamnosyl)-3-O-rutinoside reduces myocardial infarction size after coronary artery ligation in rats. Eerduna G, Wei D, Yu X, Qu S, Sui D.Pharmazie. 2013 Jun;68(6):453-8. PMID: 23875254 4:[Comparison of effects of kaempferide and anhydroicaritin on biomineralization of cultured osteoblasts]. Song P, Yao J, Ma HP, Ge BF, Chen KM, Guo XY, Lü X.Yao Xue Xue Bao. 2012 Jul;47(7):890-6. Chinese. PMID: 22993853 5:Hypolipidemic effects of kaempferide-7-O-(4/’/’-O-acetylrhamnosyl)-3-O-rutinoside in hyperlipidemic rats induced by a high-fat diet. Zhao XZ, Li XW, Jin YR, Yu XF, Qu SC, Sui DY.Mol Med Rep. 2012 Mar;5(3):837-41. doi: 10.3892/mmr.2011.714. Epub 2011 Dec 15. PMID: 22179545 6:Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Martineti V, Tognarini I, Azzari C, Carbonell Sala S, Clematis F, Dolci M, Lanzotti V, Tonelli F, Brandi ML, Curir P.Phytother Res. 2010 Sep;24(9):1302-8. doi: 10.1002/ptr.3105. PMID: 20104502 7:Studies on the homolytic and heterolytic cleavage of kaempferol and kaempferide glycosides using electrospray ionization tandem mass spectrometry. Lu L, Song FR, Tsao R, Jin YR, Liu ZQ, Liu SY.Rapid Commun Mass Spectrom. 2010 Jan;24(1):169-72. doi: 10.1002/rcm.4368. No abstract available. PMID: 19960496 8:In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide. de Monbrison F, Maitrejean M, Latour C, Bugnazet F, Peyron F, Barron D, Picot S.Acta Trop. 2006 Jan;97(1):102-7. Epub 2005 Oct 26. PMID: 16256062 9:Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Otake Y, Walle T.Drug Metab Dispos. 2002 Feb;30(2):103-5. PMID: 11792676 Free Article10:Kaempferide triglycoside: a possible factor of resistance of carnation (Dianthus caryophyllus) to Fusarium oxysporum f. sp. dianthi. Curir P, Dolci M, Lanzotti V, Taglialatela-Scafati O.Phytochemistry. 2001 Apr;56(7):717-21. PMID: 11314958