Radicicol

• CAT Number: M051541
• CAS Number: 12772-57-5
• Molecular Formula: C18H17ClO6
• Molecular Weight: 364.778
• Purity: ≥95%
• Target: HSP
• Solubility: Soluble to 25 mM in ethanol
• Storage: Store at -20°C
• InChI: InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
• InChIKey: WYZWZEOGROVVHK-GTMNPGAYSA-N
• SMILES: CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1

Radicicol is a macrolactone antibiotic. Radicicol is a tyrosine kinase inhibitor. It displays anti-angiogenic activity.

Reference

Some metabolites of Nectria radicicola Gerlach & Nilsson (syn. Cylindrocarpon radicicola Wr.): The structure of radicicol (monorden) Mirrington, R.N. et al. , Aust. J. Chem., 1966, 19, 1265.Induction of differentiation of HL-60 cells by the antifungal antibiotic, Radicicol. Shimada, Y., et al. J. Antibiot. 1995, 48, 824.Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells. Pillay, I., et al. Cell. Growth Differ. 1996, 7, 1487.Radicicol a microbial cell differentiation modulator inhibits in vivo angiogenesis. Oikawa, T., et al. Eur. J. Pharmacol. 1993, 241, 221.Suppression of RAS and MOS transformation by radicicol. Zhao, J.F., et al. Oncogene 1995, 11, 161.Chemistry and biology of resorcylic acid lactones. Winssinger N. and Barluenga S.. Chem. Commun., 2007, 22.