(Rac)-OSMI-1

• CAT Number: I045544
• CAS Number: 2748153-92-4
• Molecular Formula: C28H25N3O6S2
• Molecular Weight: 563.64
• Purity: ≥95%
• Synonyms: N-(furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-[(2-oxo-1H-quinolin-6-yl)sulfonylamino]-N-(thiophen-2-ylmethyl)acetamide
• InChI: InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)
• InChIKey: IYIGLWQQAMROOF-UHFFFAOYSA-N
• SMILES: COC1=CC=CC=C1C(C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5

(Rac)-OSMI-1 (Cat No.: I045544) is a racemic form of OSMI-1, a potent and selective O-GlcNAc transferase (OGT) inhibitor used in epigenetics and cell signaling research. By blocking OGT activity, it prevents the addition of O-GlcNAc modifications to nuclear and cytoplasmic proteins, thereby influencing transcription, signaling pathways, and stress responses. The racemic mixture includes both enantiomers, making it suitable for comparative pharmacological and biochemical studies. (Rac)-OSMI-1 is a valuable chemical probe for investigating glycosylation-dependent processes, cancer biology, and metabolic regulation.

Reference

[1]. Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.
[Content Brief]

[2]. Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.
[Content Brief]