For research use only. Not for therapeutic Use.
(Rac)-Acolbifene (CAT: R045583) is the racemic form of EM-652, a selective estrogen receptor antagonist with mixed anti-estrogenic and estrogenic activities. Containing a piperidine ring, it demonstrates a strong pharmacological profile with a relative binding affinity (RBA) of 380. In vitro, (Rac)-Acolbifene inhibits proliferation of T-47D breast cancer cells with an IC₅₀ of 0.110 nM. In vivo, oral administration (7.5–75 nM daily for 9 days) in ovariectomized mice produced 63% and 84% antiuterotrophic inhibition at respective doses, confirming its efficacy. (Rac)-Acolbifene is a valuable tool in estrogen receptor research, hormone-dependent cancer studies, and selective estrogen modulation.
| CAS Number | 151533-34-5 |
| Synonyms | 3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol |
| Molecular Formula | C29H31NO4 |
| Purity | ≥95% |
| IUPAC Name | 3-(4-hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol |
| InChI | InChI=1S/C29H31NO4/c1-20-26-14-11-24(32)19-27(26)34-29(28(20)21-5-9-23(31)10-6-21)22-7-12-25(13-8-22)33-18-17-30-15-3-2-4-16-30/h5-14,19,29,31-32H,2-4,15-18H2,1H3 |
| InChIKey | DUYNJNWVGIWJRI-UHFFFAOYSA-N |
| SMILES | CC1=C(C(OC2=C1C=CC(=C2)O)C3=CC=C(C=C3)OCCN4CCCCC4)C5=CC=C(C=C5)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
