EI1

• CAT Number: I001607
• CAS Number: 1418308-27-6
• Molecular Formula: C23H26N4O2
• Molecular Weight: 390.5
• Purity: ≥95%
• Synonyms: 6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide
• Target: EZH2
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IC50: 15±2 nM (EZH2 wild type); 13±3 nM (EZH2 Y641F mutant type) [1]
• InChI: InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
• InChIKey: PFHDWRIVDDIFRP-UHFFFAOYSA-N
• SMILES: CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C

EI1 (Cat.No:I001607) is a chemical compound with potential therapeutic applications. It acts as a selective inhibitor of enhancer of zeste homolog 2 (EZH2), an enzyme involved in epigenetic regulation. By inhibiting EZH2, EI1 shows potential in cancer treatment, particularly in inhibiting tumor growth and metastasis. Further research is ongoing to explore its efficacy and safety profiles.

Reference

[1]. Qi W, et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21360-5.