EI1 - CAS 1418308-27-6

EI1 (Cat.No:I001607) is a chemical compound with potential therapeutic applications. It acts as a selective inhibitor of enhancer of zeste homolog 2 (EZH2), an enzyme involved in epigenetic regulation. By inhibiting EZH2, EI1 shows potential in cancer treatment, particularly in inhibiting tumor growth and metastasis. Further research is ongoing to explore its efficacy and safety profiles.

Catalog Number: I001607

CAS Number: 1418308-27-6

PubChem Substance ID:355049811

Molecular Formula: C23H26N4O2

Molecular Weight:390.5

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide

Property

Molecular Formula: C23H26N4O2
Molecular Weight390.5
Target:EZH2
Solubility10 mM in DMSO
Purity≥95%
StorageStore at -20℃
IC5015±2 nM (EZH2 wild type); 13±3 nM (EZH2 Y641F mutant type) [1]

Computed Descriptor

IUPAC Name6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide
InChIInChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChIKeyPFHDWRIVDDIFRP-UHFFFAOYSA-N
SMILESCCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C