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Rabeprazole sodium

Rabeprazole sodium

  • CAT Number: I000638
  • CAS Number: 117976-90-6
  • Molecular Formula: C18H21N3O3S • Na
  • Molecular Weight: 382.42
  • Purity: ≥95%
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Rabeprazole sodium (Cat No.:I000638) is a medication belonging to the class of drugs known as proton pump inhibitors (PPIs). It is primarily used for the treatment of ulcers in the stomach and duodenum, as well as gastroesophageal reflux disease (GERD). Rabeprazole sodium works by reducing the production of stomach acid, thereby helping to alleviate symptoms and promote the healing of ulcers. It is commonly prescribed for short-term treatment and maintenance therapy in patients with acid-related disorders, providing relief and improving overall gastrointestinal health.

Catalog Number I000638
CAS Number 117976-90-6
Molecular Formula

C18H21N3O3S • Na

Purity 95%
Target Proton Pump
Solubility DMSO 48 mg/ml
Storage -20°C
IUPAC Name sodium;2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]benzimidazol-1-ide
InChI InChI=1S/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1
InChIKey KRCQSTCYZUOBHN-UHFFFAOYSA-N
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3[N-]2)OCCCOC.[Na+]
Reference

</br>1:Development and validation of dissolution testings in acidic media for rabeprazole sodium delayed-release capsules. Tan Y, Si X, Zhong L, Feng X, Yang X, Huang M, Wu C.Drug Dev Ind Pharm. 2016 Oct;42(10):1669-77. doi: 10.3109/03639045.2016.1161644. Epub 2016 Apr 11. PMID: 27066697 Free PMC Article</br>2:Development and validation of HPLC-DAD method for the simultaneous determination of amoxicillin, metronidazole and rabeprazole sodium. Application to spiked simulated intestinal fluid samples. Sabry SM, Abdel-Hay MH, Belal TS, Mahgoub AA.Ann Pharm Fr. 2015 Sep;73(5):351-60. doi: 10.1016/j.pharma.2015.04.008. Epub 2015 May 27. PMID: 26024556 </br>3:A study of selective spectrophotometric methods for simultaneous determination of Itopride hydrochloride and Rabeprazole sodium binary mixture: Resolving sever overlapping spectra. Mohamed HM.Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt C:1308-15. doi: 10.1016/j.saa.2014.10.018. Epub 2014 Oct 28. PMID: 25456673 </br>4:Liquid chromatography coupled with fluorimetric detection and third derivative synchronous fluorescence spectroscopy as two analytical methods for the simultaneous determination of rabeprazole sodium and domperidone after derivatization with 4-chloro-7-nitrobenzofurazan. Ibrahim F, Wahba ME.J Fluoresc. 2014 Jul;24(4):1137-47. doi: 10.1007/s10895-014-1394-z. Epub 2014 Jun 3. PMID: 24882601 </br>5:Development and Validation of a Stability-Indicating RP-HPLC Method for the Determination of Process-Related Impurities and Degradation Products of Rabeprazole Sodium in Pharmaceutical Formulation. Kumar N, Sangeetha D.Sci Pharm. 2013 Mar 17;81(3):697-711. doi: 10.3797/scipharm.1301-25. Print 2013 Jul-Sep. PMID: 24106668 Free PMC Article</br>6:Validation and application of a new reversed phase HPLC method for in vitro dissolution studies of rabeprazole sodium in delayed-release tablets. Nawaz MS.J Anal Methods Chem. 2013;2013:976034. doi: 10.1155/2013/976034. Epub 2013 Aug 22. PMID: 24062966 Free PMC Article</br>7:Design and characterization of enteric-coated controlled release mucoadhesive microcapsules of Rabeprazole sodium. Swain S, Behera UA, Beg S, Sruti J, Patro ChN, Dinda SC, Rao ME.Drug Dev Ind Pharm. 2013 Apr;39(4):548-60. doi: 10.3109/03639045.2012.676047. Epub 2012 Apr 18. PMID: 22512732 </br>8:Rabeprazole sodium delayed-release multiparticulates: Effect of enteric coating layers on product performance. Tirpude RN, Puranik PK.J Adv Pharm Technol Res. 2011 Jul;2(3):184-91. doi: 10.4103/2231-4040.85539. PMID: 22171316 Free PMC Article</br>9:Spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac from the combined capsule dosage form. Sawant RL, Hadawale SD, Dhikale GK, Bansode CA, Tajane PS.Pharm Methods. 2011 Jul;2(3):193-7. doi: 10.4103/2229-4708.90362. PMID: 23781455 Free PMC Article</br>10:Identification, isolation and characterization of new impurity in rabeprazole sodium. Rao PS, Ray UK, Gupta PB, Rao DV, Islam A, Rajput P, Mukkanti K.J Pharm Biomed Anal. 2010 Aug 1;52(4):620-4. doi: 10.1016/j.jpba.2010.01.034. Epub 2010 Jan 25. PMID: 20153594

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