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R406

R406

  • CAT Number: I005039
  • CAS Number: 841290-81-1
  • Molecular Formula: C22H23FN6O5.C6H6O3S
  • Molecular Weight: 628.63
  • Purity: ≥95%
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R406 (Cat. No: I005039), also known as Tamatinib, is an effective Syk inhibitor, which has a strong inhibitory effect on Syk but does not inhibit Lyn, and its effect on Flt3 is 5 times lower than that on Syk. R406 can induce apoptosis.

Catalog Number I005039
CAS Number 841290-81-1
Molecular Formula

C22H23FN6O5.C6H6O3S

Purity 95%
Target Spleen Tyrosine Kinase (Syk)
Solubility DMSO: ≥ 61 mg/mL
Storage 3 years -20C powder
IC50 41 nM [1]
Reference

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<br>[1]. Braselmann S, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther, 2006, 319(3), 998-1008.
<br>[2]. Quiroga MP, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood, 2009, 114(5), 1029-1037.
<br>[3]. Lhermusier T, et al. The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies. J Thromb Haemost, 2011, 9(10), 2067-2076.
<br>[4]. Zhu Y, et al. Immunotoxicity assessment for the novel Spleen tyrosine kinase inhibitor R406. Toxicol Appl Pharmacol, 2007, 221(3), 268-277.
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