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(R)-Irofulven

(R)-Irofulven

  • CAT Number: R048578
  • CAS Number: 158440-71-2
  • Molecular Formula: C15H18O3
  • Molecular Weight: 246.306
  • Purity: ≥95%
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(R)-Irofulven (CAS158440-71-2)is a DNA-damaging and antitumor agent for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.

Catalog Number R048578
CAS Number 158440-71-2
Synonyms

(6’R)-6’-Hydroxy-3’-(hydroxymethyl)-2’,4’,6’-trimethylspiro[cyclopropane-1,5’-[5H]inden]-7’(6’H)-one; (-)-(Hydroxymethyl)acylfulvene; (-)-Irofulven; HMAF; MGI 114; NSC 683863;

Molecular Formula

C15H18O3

Purity 95%
Storage -20°C
IUPAC Name (5/'R)-5/'-hydroxy-1/'-(hydroxymethyl)-2/',5/',7/'-trimethylspiro[cyclopropane-1,6/'-indene]-4/'-one
InChI InChI=1S/C15H18O3/c1-8-6-10-12(11(8)7-16)9(2)15(4-5-15)14(3,18)13(10)17/h6,16,18H,4-5,7H2,1-3H3/t14-/m0/s1
InChIKey NICJCIQSJJKZAH-AWEZNQCLSA-N
SMILES CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CO
Reference

<p>
<span style=”color:#000000;”><span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”>1.Staake, Michael D., et al. &quot;Hydroxyurea derivatives of irofulven with improved antitumor efficacy.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Bioorganic &amp; medicinal chemistry letters</i>&nbsp;26.7 (2016): 1836-1838.<br />
2.Tummala, Hemanth, et al. &quot;ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>The American Journal of Human Genetics</i>&nbsp;94.2 (2014): 246-256.<br />
3.Glatt, Hansruedi, et al. &quot;Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.&quot;&nbsp;<i style=”font-family: Arial, sans-serif; font-size: 13px;”>Archives of toxicology</i>&nbsp;88.1 (2014): 161-169.</span></span></span></p>

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