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(R)-(-)-Falcarinol

(R)-(-)-Falcarinol

  • CAT Number: R043227
  • CAS Number: 21852-80-2
  • Molecular Formula: C17H24O
  • Molecular Weight: 244.4
  • Purity: ≥95%
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Falcarinol is a C<sub>17</sub>-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis. Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB<sub>1</sub> and CB<sub>2</sub>, (K<sub>i</sub>s = 594 and 2,100 nM, respectively) in an [ It differentially modulates synaptic and extrasynaptic GABA<sub>A</sub> receptors in a recombinant HEK293 system. <em>In vitro</em> assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC<sub>50</sub> = 79.3 μM), a drug efflux transporter and mediator of drug resistance. Falcarinol (6.88 μg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.

Catalog Number R043227
CAS Number 21852-80-2
Molecular Formula

C17H24O

Purity 95%
Storage -20°C
InChIKey UGJAEDFOKNAMQD-QXPKXGMISA-N

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