(R)-BPO-27

• CAT Number: I013693
• CAS Number: 1415390-47-4
• Molecular Formula: C₂₆H₁₈BrN₃O₆
• Molecular Weight: 548.34
• Purity: ≥95%
• Target: CFTR
• Solubility: DMSO: ≥ 14.28 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (9R)-9-(5-bromofuran-2-yl)-12,14-dimethyl-13,15-dioxo-17-phenyl-8-oxa-1,12,14-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-2(7),3,5,10,16-pentaene-4-carboxylic acid
• InChI: InChI=1S/C26H18BrN3O6/c1-28-21-19(24(31)29(2)26(28)34)20(13-6-4-3-5-7-13)30-15-12-14(25(32)33)8-9-16(15)36-23(22(21)30)17-10-11-18(27)35-17/h3-12,23H,1-2H3,(H,32,33)/t23-/m0/s1
• InChIKey: GNHIGSRGYXEQEP-QHCPKHFHSA-N
• SMILES: CN1C2=C3C(OC4=C(N3C(=C2C(=O)N(C1=O)C)C5=CC=CC=C5)C=C(C=C4)C(=O)O)C6=CC=C(O6)Br

(R)-BPO-27（Cat No.:I013693） is a highly potent inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an IC50 value of 4 nM, indicating its strong inhibitory activity against CFTR. CFTR is a protein involved in chloride ion transport, and dysfunction of CFTR leads to cystic fibrosis. (R)-BPO-27’s ability to effectively inhibit CFTR suggests its potential application in research and potentially as a therapeutic agent for conditions associated with CFTR dysfunction.

Reference

[1]. Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459.[2]. Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96.