R 7050

• CAT Number: I011194
• CAS Number: 303997-35-5
• Molecular Formula: C16H8ClF3N4S
• Molecular Weight: 380.77
• Purity: ≥95%
• Synonyms: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
• Target: TNF-α
• Solubility: Soluble to 20 mM in DMSO
• Storage: -20°C
• IUPAC Name: 8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
• InChI: InChI=1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
• InChIKey: SUUMKHOVGVYGOP-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F

R-7050（Cat No.: I011194）, serves as a cell-permeable antagonist for the tumor necrosis factor-alpha (TNF-α) receptor. It exhibits remarkable selectivity, being 2.3 times more inclined towards inhibiting TNF-α-mediated signaling when compared to interleukin-1 beta (IL-1β)-driven signaling pathways. This selective attribute makes R-7050 a promising candidate for therapeutic interventions aimed at modulating TNF-α-related responses while sparing IL-1β-related processes. Such specificity can be advantageous in targeting specific inflammatory or immune-related conditions where TNF-α plays a crucial role, potentially leading to more precise and effective treatments.