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R-268712

R-268712

  • CAT Number: I005290
  • CAS Number: 879487-87-3
  • Molecular Formula: C20H18FN5O
  • Molecular Weight: 363.39
  • Purity: ≥95%
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R-268712 (Cat.No:I005290) is a potent and selective inhibitor of ALK5 (Activin receptor-like kinase 5), with an impressive IC50 value of 2.5 nM. ALK5 plays a crucial role in the TGF-β signaling pathway, regulating cell proliferation, differentiation, and development. R-268712 shows promise in research for potential therapeutic applications in cancer, fibrosis, and other diseases.

Catalog Number I005290
CAS Number 879487-87-3
Molecular Formula

C20H18FN5O

Purity 95%
Target ALK5
Solubility 10 mM in DMSO
Storage Desiccate at +4C
IC50 2.5 nM [1]
Reference

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<br>[1]. Terashima H, et al. R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis model. Eur J Pharmacol. 2014 Jul 5;734:60-6.

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