(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid

• CAT Number: I000220
• CAS Number: 103733-65-9
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.2
• Purity: ≥95%
• Solubility: 10 mM in DMSO, H2O: ＜ 6.2 mg/mL
• Storage: Store at -20°C

(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid(CAT: I000220), also known as (R)-Tic, is an organic compound that belongs to the class of isoquinoline carboxylic acids. It is a chiral building block that is widely used in the synthesis of pharmaceuticals, agrochemicals, and natural products. (R)-Tic is used as a starting material in the synthesis of drugs such as ropinirole, a dopamine agonist used in the treatment of Parkinson’s disease, and pramipexole, a drug used in the treatment of restless legs syndrome and Parkinson’s disease. It is also used in the synthesis of various alkaloids and natural products.

Reference

[1]. Valle G, et al. Constrained phenylalanine analogues. Preferred conformation of the 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) residue. Int J Pept Protein Res. 1992 Sep-Oct;40(3-4):222-32.