Quinidine hydrochloride monohydrate

• CAT Number: I012987
• CAS Number: 6151-40-2
• Molecular Formula: C₂₀H₂₇ClN₂O₃
• Molecular Weight: 378.89
• Purity: ≥95%
• Target: Potassium Channel
• Solubility: DMSO: 106.7 mg/mL
• IUPAC Name: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;hydrate;hydrochloride
• InChI: InChI=1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19+,20-;;/m0../s1
• InChIKey: SGVZDMWHXVXUBY-KAIFKDDSSA-N
• SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.Cl

Quinidine hydrochloride monohydrate (Cat.No:I012987) is a medication used to treat certain heart rhythm disorders, particularly those associated with atrial fibrillation and ventricular arrhythmias. It is a class I antiarrhythmic agent that works by blocking specific ion channels in the heart, regulating electrical signals and restoring normal rhythm.

Reference

[1]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.[2]. Cheng KI, et al. Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses. J Anesth. 2014 Aug;28(4):559-68.