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Quinethazone

Quinethazone

  • CAT Number: R057180
  • CAS Number: 73-49-4
  • Molecular Formula: C10H12ClN3O3S
  • Molecular Weight: 289.734
  • Purity: ≥95%
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Quinethazone is a thiazide diuretic used to treat hypertension. Common side effects include dizziness, dry mouth, nausea, and low potassium levels.

Catalog Number R057180
CAS Number 73-49-4
Synonyms

2-Ethyl-7-chloro-1,2,3,4-tetrahydro-4-oxoquinazoline-6-sulfonamide; 2-Ethyl-7-chloro-2,3-dihydro-4(1H)-quinazolone-6-sulfonamide; Aquamox; CL 36010; Hydromox; Idrokin; Quimethazin; Quinethazon; Quinethazonum; 7-Chloro-2-ethyl-1,2,3,4-tetrahydro-4-oxo

Molecular Formula

C10H12ClN3O3S

Purity 95%
Storage Store at +4C
IUPAC Name 7-chloro-2-ethyl-4-oxo-2,3-dihydro-1H-quinazoline-6-sulfonamide
InChI InChI=1S/C10H12ClN3O3S/c1-2-9-13-7-4-6(11)8(18(12,16)17)3-5(7)10(15)14-9/h3-4,9,13H,2H2,1H3,(H,14,15)(H2,12,16,17)
InChIKey AGMMTXLNIQSRCG-UHFFFAOYSA-N
SMILES CCC1NC2=CC(=C(C=C2C(=O)N1)S(=O)(=O)N)Cl
Reference

</br>1:Guancydine: a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol. Clark DW, Goldberg LI.Ann Intern Med. 1972 Apr;76(4):579-85. No abstract available. PMID: 4565483 </br>2:The supra-additive natriuretic effect addition of quinethazone or bendroflumethiazide during long-term treatment with furosemide and spironolactone. Permutation trial tests in patients with congestive heart failure. Olesen KH, Sigurd B.Acta Med Scand. 1971 Sep;190(3):233-40. No abstract available. PMID: 4941227 </br>3:The natriuretic effect addition of quinethazone and furosemide in congestive heart failure. A permutation trial test. Olesen KH.Acta Med Scand. 1971 Sep;190(3):229-32. No abstract available. PMID: 4941226 </br>4:Technique of controlled drug assay in hypertension. V. Comparison of hydrochlorothiazide with a new quinethazone diuretic, metolazone. Pilewski RM, Scheib ET, Misage JR, Kessler E, Krifcher E, Shapiro AP.Clin Pharmacol Ther. 1971 Sep-Oct;12(5):843-8. No abstract available. PMID: 4936150 </br>5:[Antidiuretic effect of quinethazone in diabetes insipidus]. Zeneroli ML.Endocrinol Sci Cost. 1970 May;31(2):135-40. Italian. No abstract available. PMID: 5470189 </br>6:The combined diuretic action of quinethazone and furosemide in congestive heart failure. A permutation trial test. Olesen KH, Dupont B, Flensted-Jensen E.Acta Med Scand. 1970 Jan-Feb;187(1-2):33-40. No abstract available. PMID: 4912468 </br>7:Treatment of hypertension with quinethazone alone or in combination with reserpine. Parkes WE, Agarwal AP, Hunt LB.Practitioner. 1969 Aug;203(214):194-8. No abstract available. PMID: 4896145 </br>8:A comparison of the hyperuricaemic effect of chlorothiazide and quinethazone. Mathew TH, Kincaid-Smith P, Doyle AE, Baird CW.Med J Aust. 1967 Mar 11;1(10):493-5. No abstract available. PMID: 6022910 </br>9:[Quinethazone-K in arterial hypertension]. Romero RL, Maljar L, Valdivia-Velarde H, Vives C, Toffoli de Matheos M.Rev Clin Esp. 1967 Jan 31;104(2):139-47. Spanish. No abstract available. PMID: 5596061 </br>10:[On the treatment of hypertension in aged with quinethazone-reserpine-potassium]. Ludwig HJ, Rahnema A.Med Welt. 1966 Nov 19;47:2560-5. German. No abstract available. PMID: 5955414

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