Pyrilamine Maleate Salt

• CAT Number: R048721
• CAS Number: 59-33-6
• Molecular Formula: C21H27N3O5
• Molecular Weight: 401.463
• Purity: ≥95%
• Synonyms: N1-[(4-Methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-1,2-ethanediamine (2Z)-2-Butenedioate; N-[(4-Methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-?1,2-ethanediamine (2Z)-2-Butenedioate; Bimaleate; AH; Anisopyradamine; Diaminide Maleate; Mepy
• Target: Histamine Receptor
• Solubility: Soluble to 10 mM in sterile water
• Storage: Store at RT
• IUPAC Name: (Z)-but-2-enedioic acid;N/'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N/'-pyridin-2-ylethane-1,2-diamine
• InChI: InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: JXYWFNAQESKDNC-BTJKTKAUSA-N
• SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O

Mepyramine maleate is a histamine H1 receptor antagonist and binds with high affinity to G(q/11) protein. Mepyramine maleate is found to be a potent inhibitor of CYP2D6 in hepatocytes. Mepyramine maleate is commonly utilized as a radioligand binding assay for the H1 receptor. This product has been recently discovered to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Reference

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