pyrante

  • CAT Number: M079799
  • CAS Number: 15686-83-6
  • Molecular Formula: C11H14N2S
  • Molecular Weight: 206.307
  • Purity: ≥95%
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Pyrantel is a nicotinic receptor agonist. Pyrantel is a depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes.

Catalog Number M079799
CAS Number 15686-83-6
Molecular Formula

C11H14N2S

Purity 95%
Target nicotinic receptor agonist
Storage -20°C
IUPAC Name 1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine
InChI InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+
InChIKey YSAUAVHXTIETRK-AATRIKPKSA-N
SMILES CN1CCCN=C1C=CC2=CC=CS2
Reference

</br>1: Abongwa M, Buxton SK, Robertson AP, Martin RJ. Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. PLoS One. 2016 Jan 11;11(1):e0146854. doi: 10.1371/journal.pone.0146854. eCollection 2016. PubMed PMID: 26751958; PubMed Central PMCID: PMC4709073.</br>2: Klausz G, Keller É, Sára Z, Székely-Körmöczy P, Laczay P, Ary K, Sótonyi P, Róna K. Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry. Biomed Chromatogr. 2015 Dec;29(12):1859-65. doi: 10.1002/bmc.3507. Epub 2015 Jun 24. PubMed PMID: 26104502.</br>3: Lawson E, Burden F, Elsheikha HM. Pyrantel resistance in two herds of donkey in the UK. Vet Parasitol. 2015 Jan 30;207(3-4):346-9. doi: 10.1016/j.vetpar.2014.12.026. Epub 2014 Dec 30. PubMed PMID: 25576440.</br>4: Armstrong SK, Woodgate RG, Gough S, Heller J, Sangster NC, Hughes KJ. The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia. Vet Parasitol. 2014 Oct 15;205(3-4):575-80. doi: 10.1016/j.vetpar.2014.08.028. Epub 2014 Sep 6. PubMed PMID: 25224788.</br>5: Gokbulut C, Aksit D, Smaldone G, Mariani U, Veneziano V. Plasma pharmacokinetics, faecal excretion and efficacy of pyrantel pamoate paste and granule formulations following per os administration in donkeys naturally infected with intestinal strongylidae. Vet Parasitol. 2014 Sep 15;205(1-2):186-92. doi: 10.1016/j.vetpar.2014.06.026. Epub 2014 Jun 26. PubMed PMID: 25015542.</br>6: Lassen B, Peltola SM. Anthelmintic resistance of intestinal nematodes to ivermectin and pyrantel in Estonian horses. J Helminthol. 2015 Nov;89(6):760-3. doi: 10.1017/S0022149X14000510. Epub 2014 Jul 9. PubMed PMID: 25007041.</br>7: Reinemeyer CR, Prado JC, Andersen UV, Nielsen MK, Schricker B, Kennedy T. Effects of daily pyrantel tartrate on strongylid population dynamics and performance parameters of young horses repeatedly infected with cyathostomins and Strongylus vulgaris. Vet Parasitol. 2014 Aug 29;204(3-4):229-37. doi: 10.1016/j.vetpar.2014.05.034. Epub 2014 May 27. PubMed PMID: 24929448.</br>8: Spodniewska A. Glutathione and glutathione-related enzymes in rats exposed to dimethoate and/or pyrantel. Pol J Vet Sci. 2014;17(1):105-12. PubMed PMID: 24724477.</br>9: Piantavini MS, Pontes FL, Uber CP, Stremel DP, Sena MM, Pontarolo R. Chemometric quality inspection control of pyrantel pamoate, febantel and praziquantel in veterinary tablets by mid infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2014 May 5;125:396-403. doi: 10.1016/j.saa.2014.01.078. Epub 2014 Jan 24. PubMed PMID: 24566119.</br>10: Nielsen MK, Vidyashankar AN, Hanlon BM, Diao G, Petersen SL, Kaplan RM. Hierarchical model for evaluating pyrantel efficacy against strongyle parasites in horses. Vet Parasitol. 2013 Nov 8;197(3-4):614-22. doi: 10.1016/j.vetpar.2013.04.036. Epub 2013 Apr 26. PubMed PMID: 23680542.</br>11: Taweethavonsawat P, Chungpivat S, Watanapongchati S, Traub RJ, Schaper R. Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender ®, Bayer) and praziquantel and pyrantel oral tablets (Drontal ® for Cats) against experimental Ancylostoma ceylanicum infections in cats. Vet Parasitol. 2013 Jan 16;191(1-2):172-6. doi: 10.1016/j.vetpar.2012.08.024. Epub 2012 Sep 4. PubMed PMID: 23026558.</br>12: Barski D, Spodniewska A. Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate. Pol J Vet Sci. 2012;15(2):239-45. PubMed PMID: 22844700.</br>13: Ohnishi K, Kobayashi K, Iwabuchi S, Nakamura-Uchiyama F. [Albendazole in Japanese juvenile with enterobiasis in whom pyrantel pamoate is not effective]. Kansenshogaku Zasshi. 2011 Sep;85(5):520-2. Japanese. PubMed PMID: 22117382.</br>14: Näreaho A, Vainio K, Oksanen A. Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. Vet Parasitol. 2011 Dec 15;182(2-4):372-7. doi: 10.1016/j.vetpar.2011.05.045. Epub 2011 May 31. PubMed PMID: 21689886.</br>15: Ferrara P, Bersani I, Bottaro G, Vitelli O, Liberatore P, Gatto A, del Bufalo F, Romano V, Stabile A. Massive proteinuria: a possible side effect of pyrantel pamoate? Ren Fail. 2011;33(5):534-6. doi: 10.3109/0886022X.2011.573894. Epub 2011 Apr 18. PubMed PMID: 21500989.</br>16: Lyons ET, Tolliver SC, Kuzmina TA, Collins SS. Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010). Parasitol Res. 2011 Oct;109(4):1193-7. doi: 10.1007/s00436-011-2379-3. Epub 2011 Apr 16. PubMed PMID: 21499750.</br>17: Hausen MA, Menna-Barreto RF, Lira DC, de Carvalho L, Barbosa HS. Synergic effect of metronidazole and pyrantel pamoate on Giardia lamblia. Parasitol Int. 2011 Jan;60(1):54-8. doi: 10.1016/j.parint.2010.10.003. Epub 2010 Oct 12. PubMed PMID: 20946968.</br>18: Gupta VK, Jain R, Jadon N, Radhapyari K. Adsorption of pyrantel pamoate on mercury from aqueous solutions: studies by stripping voltammetry. J Colloid Interface Sci. 2010 Oct 1;350(1):330-5. doi: 10.1016/j.jcis.2010.06.056. Epub 2010 Jul 1. PubMed PMID: 20643413.</br>19: Cirak VY, Kar S, Girişgin O. [A survey on anthelmintic resistance in Strongyles to ivermectin and pyrantel and macrocyclic lactone-resistance in Parascaris equorum]. Turkiye Parazitol Derg. 2010;34(1):35-9. Turkish. PubMed PMID: 20340086.</br>20: Reinemeyer CR, Prado JC, Nichols EC, Marchiondo AA. Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses. Vet Parasitol. 2010 Jul 15;171(1-2):111-5. doi: 10.1016/j.vetpar.2010.02.041. Epub 2010 Mar 4. PubMed PMID: 20307936.</br></br>

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