For research use only. Not for therapeutic Use.
PXS-5120A（Cat No.:I017734）is a potent and selective inhibitor of lysyl oxidase-like 2 (LOXL2), an enzyme involved in collagen crosslinking and extracellular matrix remodeling. By blocking LOXL2 activity, PXS-5120A helps reduce tissue fibrosis and stiffness, making it a valuable tool for studying fibrotic diseases such as idiopathic pulmonary fibrosis, liver fibrosis, and cardiac fibrosis. Its oral bioavailability and strong target engagement support its use in both in vivo and in vitro research. PXS-5120A offers significant potential for advancing anti-fibrotic therapeutic development.
| CAS Number | 2125955-70-4 |
| Synonyms | 1-[(Z)-4-amino-2-fluorobut-2-enyl]-3-[3-(dimethylsulfamoyl)phenyl]-2-methylindole-5-carboxylic acid;hydrochloride |
| Molecular Formula | C22H25ClFN3O4S |
| Purity | ≥95% |
| IUPAC Name | 1-[(Z)-4-amino-2-fluorobut-2-enyl]-3-[3-(dimethylsulfamoyl)phenyl]-2-methylindole-5-carboxylic acid;hydrochloride |
| InChI | InChI=1S/C22H24FN3O4S.ClH/c1-14-21(15-5-4-6-18(11-15)31(29,30)25(2)3)19-12-16(22(27)28)7-8-20(19)26(14)13-17(23)9-10-24;/h4-9,11-12H,10,13,24H2,1-3H3,(H,27,28);1H/b17-9-; |
| InChIKey | PWSRWJMEGVKWES-WPTDRQDKSA-N |
| SMILES | CC1=C(C2=C(N1C/C(=C/CN)/F)C=CC(=C2)C(=O)O)C3=CC(=CC=C3)S(=O)(=O)N(C)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
