PTP1B-IN-9

• CAT Number: I016708
• CAS Number: 145888-79-5
• Molecular Formula: C₁₉H₁₃Cl₄NO
• Molecular Weight: 413.12
• Purity: ≥95%

PTP1B-IN-9(CAT: I016708) is a ubiquitin-proteasome system (UPS)-a stressor that inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activities. This leads to a UPS-stress response without affecting 20S proteasome catalytic activities. PTP1B-IN-9 has shown anticancer activity by reducing the viability of HPV16-positive SiHa and Caski cells as well as HPV-39-positive ME180 cervical cancer cell lines in a dose-dependent manner. It also reduces the cell viability of HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM.

Reference

[1]. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.