Psoromic Acid

• CAT Number: R067100
• CAS Number: 7299-11-8
• Molecular Formula: C18H14O8
• Molecular Weight: 358.302
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 10-formyl-9-hydroxy-3-methoxy-4,7-dimethyl-6-oxobenzo[b][1,4]benzodioxepine-1-carboxylic acid
• InChI: InChI=1S/C18H14O8/c1-7-4-11(20)10(6-19)15-13(7)18(23)26-14-8(2)12(24-3)5-9(17(21)22)16(14)25-15/h4-6,20H,1-3H3,(H,21,22)
• InChIKey: FUCWJKJZOHOLEO-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C2=C1C(=O)OC3=C(O2)C(=CC(=C3C)OC)C(=O)O)C=O)O

Psoromic acid is an inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum fatty acid synthesis (FAS) II. It shows cytotoxic effects on primary rat cerebral cortex and human cancer U87MG cell lines in vitro (IC50s = 79.40 and 56.22 mg/L, respectively). It also is cytotoxic against human KB cancer cells (IC50 = 31.6 µM). It shows moderate activity against liver stage P. beghei (IC50 = 31.6 µM) and drug-resistant blood stage P. falciparum (IC50 = 29.2 µM). The maximum tolerated dose in zebrafish larvae is 15.5 µM.