PSN632408

• CAT Number: I005154
• CAS Number: 857652-30-3
• Molecular Formula: C18H24N4O4
• Molecular Weight: 360.4
• Purity: ≥95%
• Target: GPR119
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 5.6/7.9 uM ( recombinant mouse/ human GPR119) [1]
• InChIKey: LHZWKWCEAXQUMX-UHFFFAOYSA-N
• SMILES: O=C(OC(C)(C)C)N1CCC(OCc2onc(n2)c2ccncc2)CC1

PSN632408 (CAT: I0051543) is an optimized agonist of GPR119 receptors, which are involved in glucose homeostasis and insulin secretion. It has been found to exhibit similar potency to OEA (oleoylethanolamide) at both recombinant mouse and human GPR119 receptors, with EC50 values of 5.6 and 7.9 μM, respectively. As an agonist, PSN632408 activates GPR119 receptors, leading to the release of incretin hormones and enhanced glucose-dependent insulin secretion. This compound holds the potential for the development of therapeutic agents targeting GPR119 receptors to regulate glucose metabolism and potentially treat conditions such as type 2 diabetes mellitus.

Reference

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