PSI-6130

• CAT Number: I004964
• CAS Number: 817204-33-4
• Molecular Formula: C10H14FN3O4
• Molecular Weight: 259.2
• Purity: ≥95%
• Synonyms: 4-amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
• Target: HCV Protease
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: NYPIRLYMDJMKGW-VPCXQMTMSA-N

PSI-6130 (CAT: I004964) is a potent and selective inhibitor of hepatitis C virus (HCV) NS5B polymerase. It is a nucleotide analog inhibitor that specifically targets the RNA-dependent RNA polymerase activity of the NS5B enzyme, which is essential for viral replication. By inhibiting NS5B, PSI-6130 disrupts viral RNA synthesis and replication, leading to the suppression of HCV replication. Its antiviral activity has been demonstrated in preclinical studies, and it has shown potential as a therapeutic agent for the treatment of hepatitis C.

Reference

1:A general and enantioselective approach to pentoses: a rapid synthesis of PSI-6130, the nucleoside core of sofosbuvir. Peifer M, Berger R, Shurtleff VW, Conrad JC, MacMillan DW.J Am Chem Soc. 2014 Apr 23;136(16):5900-3. doi: 10.1021/ja502205q. Epub 2014 Apr 9. PMID: 24670208 Free PMC Article2:An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. Wang P, Chun BK, Rachakonda S, Du J, Khan N, Shi J, Stec W, Cleary D, Ross BS, Sofia MJ.J Org Chem. 2009 Sep 4;74(17):6819-24. doi: 10.1021/jo901345j. PMID: 19642660 3:Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Ali S, Leveque V, Le Pogam S, Ma H, Philipp F, Inocencio N, Smith M, Alker A, Kang H, Najera I, Klumpp K, Symons J, Cammack N, Jiang WR.Antimicrob Agents Chemother. 2008 Dec;52(12):4356-69. doi: 10.1128/AAC.00444-08. Epub 2008 Oct 6. PMID: 18838588 Free PMC Article4:Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2/’-Deoxy-2/’-fluoro-2/’-C-methylcytidine (PSI-6130) and identification of a novel active 5/’-triphosphate species. Ma H, Jiang WR, Robledo N, Leveque V, Ali S, Lara-Jaime T, Masjedizadeh M, Smith DB, Cammack N, Klumpp K, Symons J.J Biol Chem. 2007 Oct 12;282(41):29812-20. Epub 2007 Aug 13. PMID: 17698842 Free Article