PSB1114

• CAT Number: I008899
• CAS Number: 1657025-60-9
• Molecular Formula: C10H11F2N2Na4O13P3S
• Molecular Weight: 622.136
• Purity: ≥95%
• Target: P2Y Receptor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: tetrasodium;[difluoro(phosphonato)methyl]-[[(2R,3S,4R)-3,4-dihydroxy-5-(2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy-oxidophosphoryl]oxyphosphinate
• InChI: InChI=1S/C10H15F2N2O13P3S.4Na/c11-10(12,28(18,19)20)29(21,22)27-30(23,24)25-3-4-6(15)7(16)8(26-4)14-2-1-5(31)13-9(14)17;;;;/h1-2,4,6-8,15-16H,3H2,(H,21,22)(H,23,24)(H,13,17,31)(H2,18,19,20);;;;/q;4*+1/p-4/t4-,6-,7-,8?;;;;/m1..../s1
• InChIKey: KATPYMNMKKBLAH-GENVZAMMSA-J
• SMILES: C1=CN(C(=O)NC1=S)C2C(C(C(O2)COP(=O)([O-])OP(=O)(C(F)(F)P(=O)([O-])[O-])[O-])O)O.[Na+].[Na+].[Na+].[Na+]

PSB1114 (CAT: I0088999) is a potent and selective agonist of the P2Y2 receptor, a subtype of purinergic receptors involved in cellular signaling. PSB1114 has a low concentration required for half-maximal activation (EC50) of approximately 0.134 μM. It exhibits significant selectivity for the P2Y2 receptor, with over 60-fold selectivity compared to P2Y4 and P2Y6 receptors. The activation of P2Y2 receptors by PSB1114 can modulate various cellular responses and signaling pathways associated with purinergic signaling, making it a valuable tool in pharmacological and biological research.

Reference

1. El-Tayeb et al (2011) Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J.Med.Chem. 54 2878. PMID: 21417463.