PS-341- CAS 179324-69-7

Bortezomib is a dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.

Catalog Number: A000254

CAS Number: 179324-69-7

PubChem Substance ID:355040070

Molecular Formula: C₁₉H₂₅BN₄O₄

Molecular Weight:384.24

Purity: ≥95%

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Synonym

SynonymsLDP-341, MLM341

Property

Molecular Formula: C₁₉H₂₅BN₄O₄
Molecular Weight384.24
Target:Proteasome
Solubility>19.2mg/mL in DMSO
Purity≥95%
Storage3 years -20C powder
MDLMFCD09056737

Computed Descriptor

InChIInChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKeyGXJABQQUPOEUTA-RDJZCZTQSA-N
SMILESB(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O