MI-2- CAS 1271738-62-5


MI-2 is a Menin-MLL interaction inhibitor with IC50 value of 446 ± 28 nM.

IC50 value: 446 ± 28 nM [1]

Target: Menin-MLL

in vitro: The menin-MLL inhibitors very effectively blocked proliferation of MLL-AF9 and MLL-ENL transduced BMC, with GI50 values of about 5 μM for MI-2 and MI-3. MI-2 and MI-3 showed only a small effect on the cell growth of E2A-HLF transduced BMC (GI50 > 50 μM). MI-2 and MI-3 substantially and specifically reduce the immortalization potential of cells transformed with MLL fusion oncoproteins [1].

in vivo: MLL-AF9 transformed BMC that remained viable after 7 days of treatment with MI-2 and MI-3 showed substantial changes in morphology, indicative of monocytic differentiation, as evidenced by increased cell size, lower nuclear to cytoplasmic ratio and highly vacuolated cytoplasm. Consistent with the change in cell morphology, the expression of CD11b was substantially increased on MLL-AF9 transformed BMC after 7 days of treatment with MI-2 and MI-3 [1].

Catalog Number: I001086

CAS Number: 1271738-62-5

PubChem Substance ID:355040317

Molecular Formula: C₁₈H₂₅N₅S₂

Molecular Weight:375.55

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine

Property

Molecular Formula: C₁₈H₂₅N₅S₂
Molecular Weight375.55
Target:Menin-MLL
Solubilityin DMSO > 10 mM
Purity≥95%
StorageStore at -20°C
IC50446 ± 28 nM [1]

Computed Descriptor

InChIInChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
InChIKeySRQYLNYQAPCPIR-UHFFFAOYSA-N
SMILESCCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C