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Prucalopride Succinate

Prucalopride Succinate

  • CAT Number: I008890
  • CAS Number: 179474-85-2 (Succinate); 179474-81-8 (free base).
  • Molecular Formula: C22H32ClN3O7
  • Molecular Weight: 485.962
  • Purity: ≥95%
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Prucalopride, also known as R-108512, is a selective, high affinity serotonin (5-HT4) receptor agonist with enterokinetic activities. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation. Prucalopride was approved for use in Europe in 2009.

Catalog Number I008890
CAS Number 179474-85-2 (Succinate); 179474-81-8 (free base).
Synonyms

R-108512; R 108512; R108512; Prucalopride Succinate; Resolor; Resotran.;4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate

Molecular Formula

C22H32ClN3O7

Purity 95%
Target 5-HT4 agonist
Solubility Soluble in DMSO, not in water
Storage 0 - 4 °C for short term, or -20 °C for long term
Reference

</br>1:Selective separation and characterisation of stress degradation products and process impurities of prucalopride succinate by LC-QTOF-MS/MS. Mahamuni BS, Jajula A, Awasthi A, Kalariya PD, Talluri MV.J Pharm Biomed Anal. 2016 Jun 5;125:219-28. doi: 10.1016/j.jpba.2016.03.047. Epub 2016 Mar 24. PMID: 27037978 </br>2:Prucalopride succinate for the treatment of constipation: an update. Bassotti G, Gambaccini D, Bellini M.Expert Rev Gastroenterol Hepatol. 2016;10(3):291-300. doi: 10.1586/17474124.2016.1129897. Epub 2016 Jan 29. Review. PMID: 26647167

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