Protirelin

• CAT Number: A000039
• CAS Number: 24305-27-9
• Molecular Formula: C16H22N6O4
• Molecular Weight: 362.39
• Purity: ≥95%
• Storage: Store at +4C
• IUPAC Name: (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
• InChI: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• InChIKey: XNSAINXGIQZQOO-SRVKXCTJSA-N
• SMILES: C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N

Protirelin, also known as Thyrel TRH, is a thyrotropin-releasing hormone receptor used totreat hypothyroidism. Protirelin stimulates release of a hormone called thyroid-stimulating hormone, or TSH, from the anterior pituitary gland.

Reference

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between chronobiological thyrotropin and prolactin responses to protirelin (TRH)
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3: Nie Y, Schoepp DD, Klaunig JE, Yard M, Lahiri DK, Kubek MJ.
Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated
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4: Smyth DG, del Rio-Garcia J, Wallnöfer H, Gogl H, Simma W, Huber A, Embacher R,
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6: Ciffo F, Bartoli V, Puglisi E, Scebba C, Munda M, Parisi W, Murgia P. [The
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7: Eulry F, Mayaudon H, Bauduceau B, Lechevalier D, Crozes P, Magnin J,
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8: Caraccio N, Monzani F, Casolaro A, Pucci E, Luisi M, Franchi F. [Tolerance of
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9: Eulry F, Bauduceau B, Bouée S, Crozes P, Magnin J, Mayaudon H, Lechevalier D.
[Prolactin response to protirelin in reactive arthritis and ankylosing
spondyloarthritis. Failure of treatment of 4 reactive arthritis with
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7858584.

10: Garbutt JC, Mayo JP, Little KY, Gillette GM, Mason GA, Dew B, Prange AJ Jr.
Dose-response studies with protirelin. Arch Gen Psychiatry. 1994
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