PROTAC MDM2 Degrader-3

• CAT Number: I018607
• CAS Number: 2249750-23-8
• Molecular Formula: C₇₂H₇₈Cl₄N₈O₁₅
• Molecular Weight: 1437.25
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 2-[2-[2-[2-[2-[4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetyl]oxyethoxy]ethoxy]ethoxy]ethyl 2-[4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]-2-oxopiperazin-1-yl]acetate
• InChI: InChI=1S/C72H78Cl4N8O15/c1-45(2)98-59-39-55(91-5)23-25-57(59)69-77-65(47-7-15-51(73)16-8-47)67(49-11-19-53(75)20-12-49)83(69)71(89)81-29-27-79(61(85)41-81)43-63(87)96-37-35-94-33-31-93-32-34-95-36-38-97-64(88)44-80-28-30-82(42-62(80)86)72(90)84-68(50-13-21-54(76)22-14-50)66(48-9-17-52(74)18-10-48)78-70(84)58-26-24-56(92-6)40-60(58)99-46(3)4/h7-26,39-40,45-46,65-68H,27-38,41-44H2,1-6H3/t65-,66-,67+,68+/m0/s1
• InChIKey: KECKJSNYFPFODX-PINBWVOXSA-N
• SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCN(C(=O)C3)CC(=O)OCCOCCOCCOCCOC(=O)CN4CCN(CC4=O)C(=O)N5C(C(N=C5C6=C(C=C(C=C6)OC)OC(C)C)C7=CC=C(C=C7)Cl)C8=CC=C(C=C8)Cl)C9=CC=C(C=C9)Cl)C1=CC=C(C=C1)Cl

PROTAC MDM2 Degrader-3 (Cat No.:I018607) is a chemical compound that has been identified as a potential small-molecule drug candidate for the treatment of cancer. It is designed to target and degrade MDM2, a protein that is often overexpressed in cancer cells and can inhibit the activity of the tumor suppressor protein p53. By degrading MDM2, PROTAC MDM2 Degrader-3 may help to restore p53 activity and trigger programmed cell death in cancer cells.

Reference

[1]. Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A.