For research use only. Not for therapeutic Use.
PROTAC HSP90 degrader BP3（Cat No.:I044122）is a bifunctional molecule designed to selectively degrade Heat Shock Protein 90 (HSP90), a molecular chaperone critical for the stability and function of numerous oncogenic proteins. Utilizing PROTAC (Proteolysis Targeting Chimera) technology, BP3 recruits HSP90 to the cellular E3 ubiquitin ligase system, triggering its ubiquitination and subsequent proteasomal degradation. This targeted degradation disrupts multiple signaling pathways involved in cancer progression, cell survival, and metastasis. BP3 is a valuable tool in cancer research, enabling precise investigation of HSP90-dependent mechanisms and evaluation of novel targeted protein degradation therapies.
| CAS Number | 2669072-88-0 |
| Synonyms | 4-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]but-3-ynylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Molecular Formula | C32H29ClN8O5 |
| Purity | ≥95% |
| IUPAC Name | 4-[4-[2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]pyrrolo[2,3-d]pyrimidin-5-yl]but-3-ynylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| InChI | InChI=1S/C32H29ClN8O5/c1-16-13-36-21(17(2)26(16)46-3)15-40-14-18(24-27(33)38-32(34)39-28(24)40)7-4-5-12-35-20-9-6-8-19-25(20)31(45)41(30(19)44)22-10-11-23(42)37-29(22)43/h6,8-9,13-14,22,35H,5,10-12,15H2,1-3H3,(H2,34,38,39)(H,37,42,43) |
| InChIKey | ZSERQSKFLSKTGE-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(C(=C1OC)C)CN2C=C(C3=C2N=C(N=C3Cl)N)C#CCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
