CONTACT US
Home > Inhibitors/Agonists>PROTACs> > PROTAC FKBP Degrader-3
PROTAC FKBP Degrader-3

PROTAC FKBP Degrader-3

  • CAT Number: I016232
  • CAS Number: 2079056-43-0
  • Molecular Formula: C₆₈H₉₀N₆O₁₇S
  • Molecular Weight: 1295.54
  • Purity: ≥95%
Inquiry Now

PROTAC FKBP Degrader-3 (Cat.No:I016232) is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].<br>PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].

Catalog Number I016232
CAS Number 2079056-43-0
Molecular Formula

C₆₈H₉₀N₆O₁₇S

Purity 95%
Reference

[1]. Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!