PROTAC Bcl2 degrader-1

• CAT Number: I018112
• CAS Number: 2378801-85-3
• Molecular Formula: C₄₅H₄₅BrN₆O₁₀S
• Molecular Weight: 941.84
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[2-[6-(4-bromophenyl)sulfanyl-1,3-dioxobenzo[de]isoquinolin-2-yl]ethyl]-N'-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]hexanediamide
• InChI: InChI=1S/C45H45BrN6O10S/c46-27-11-13-28(14-12-27)63-35-17-15-32-39-29(35)5-3-6-30(39)42(57)51(43(32)58)22-19-48-36(53)9-1-2-10-37(54)49-21-24-62-26-25-61-23-20-47-33-8-4-7-31-40(33)45(60)52(44(31)59)34-16-18-38(55)50-41(34)56/h3-8,11-15,17,34,47H,1-2,9-10,16,18-26H2,(H,48,53)(H,49,54)(H,50,55,56)
• InChIKey: IUSLKFLLLNNOGR-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCNC(=O)CCCCC(=O)NCCN4C(=O)C5=C6C(=C(C=C5)SC7=CC=C(C=C7)Br)C=CC=C6C4=O

PROTAC Bcl2 degrader-1 ( Cat No. : I018112 ) is a PROTAC that effectively and specifically induces Bcl-2 ( IC50,4.94 μM ) by introducing the E3 ligase cereblon ligand pomalidomide into the Mcl-1 / Bcl-2 dual inhibitor Nap-1. DC50, 3.0 μM ) and Mcl-1 ( IC50, 11.81 μM ). If you need, please contact us in time, and we will reply as soon as possible within 24 hours.

Reference

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.