Propranolol Hydrochloride

• CAT Number: I008886
• CAS Number: 3506-09-0
• Molecular Formula: C16H22ClNO2
• Molecular Weight: 295.807
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: -20°C
• IUPAC Name: 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride
• InChI: InChI=1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
• InChIKey: ZMRUPTIKESYGQW-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl

Propranolol hydrochloride is a cationic molecule shown to block β1 and β2 adrenergic receptors. Propranolol hydrochloride also has been shown to inhibit the formation of phospholipase D-derived diacylglycerol by inhibiting cytosolic phosphatidate phosphohydrolase; making propranolol a useful tool for investigating phospholipase D-, and phospholipase C-mediated DAG production. Propranolol hydrochloride is an inhibitor of AR.

Reference

1:Transdermal delivery of propranolol hydrochloride through chitosan nanoparticles dispersed in mucoadhesive gel. Al-Kassas R, Wen J, Cheng AE, Kim AM, Liu SS, Yu J.Carbohydr Polym. 2016 Nov 20;153:176-86. doi: 10.1016/j.carbpol.2016.06.096. Epub 2016 Jun 25. PMID: 27561485 2:Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride. Vakili H, Nyman JO, Genina N, Preis M, Sandler N.Int J Pharm. 2016 Sep 10;511(1):606-18. doi: 10.1016/j.ijpharm.2016.07.032. Epub 2016 Jul 18. PMID: 27444550 3:[Effects of topical propranolol hydrochloride gel for treatment of infantile hemangioma in nude mice]. Shuming C, Shaoquan C, Zaizhong Z, Chengjin L, Yin X, Chen L, Qingjin H, Lie W.Zhonghua Zheng Xing Wai Ke Za Zhi. 2015 Nov;31(6):446-50. Chinese. PMID: 27055325 4:Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride. Abruzzo A, Cerchiara T, Bigucci F, Gallucci MC, Luppi B.J Pharm Sci. 2015 Dec;104(12):4365-72. doi: 10.1002/jps.24688. Epub 2015 Oct 27. PMID: 26505621 5:Propranolol hydrochloride-loaded liposomal gel for transdermal delivery: Characterization and in vivo evaluation. Guan Y, Zuo T, Chang M, Zhang F, Wei T, Shao W, Lin G.Int J Pharm. 2015 Jun 20;487(1-2):135-41. doi: 10.1016/j.ijpharm.2015.04.023. Epub 2015 Apr 13. PMID: 25882014 6:Determination of propranolol hydrochloride in pharmaceutical preparations using near infrared spectrometry with fiber optic probe and multivariate calibration methods. Marques Junior JM, Muller AL, Foletto EL, da Costa AB, Bizzi CA, Irineu Muller E.J Anal Methods Chem. 2015;2015:795102. doi: 10.1155/2015/795102. Epub 2015 Mar 12. PMID: 25861516 Free PMC Article7:Ecotoxicological evaluation of propranolol hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in binary mixtures. Godoy AA, Kummrow F, Pamplin PA.Ecotoxicology. 2015 Jul;24(5):1112-23. doi: 10.1007/s10646-015-1455-3. Epub 2015 Apr 7. PMID: 25847105 8:Effects of (R)- and (S)-propranolol hydrochloride enantiomers on the resonance Rayleigh scattering spectra with erythrosine B as probe and their analytical applications. Yang J, Wang E, Zhou S, Yang Q.Talanta. 2015 Mar;134:754-60. doi: 10.1016/j.talanta.2014.12.030. Epub 2014 Dec 30. PMID: 25618732 9:The role of co-spray-drying procedure in the preformulation of intranasal propranolol hydrochloride. Ambrus R, Gergely M, Zvonar A, Szabó-Révész P, Sipos E.Acta Chim Slov. 2014;61(3):601-7. PMID: 25286216 10:Characterization and human osteoblastic proliferation- and differentiation-stimulatory effects of phosphatidylcholine liposomes-encapsulated propranolol hydrochloride. Teong B, Kuo SM, Chen CH, Chen YK, Cheng ZJ, Huang HH.Biomed Mater Eng. 2014;24(5):1875-87. doi: 10.3233/BME-140997. PMID: 25201400