Progesterone

• CAT Number: A000250
• CAS Number: 57-83-0
• Molecular Formula: C21H30O2
• Molecular Weight: 314.5
• Purity: ≥95%
• Target: Estrogen/progestogen Receptor
• Solubility: >14.7mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• InChIKey: RJKFOVLPORLFTN-LEKSSAKUSA-N
• SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Progesterone is the biosynthetic precursor of all other steroid hormones. Progesterone induces maturation and secretory activity of the uterine endothelium while suppressing ovulation. Progesterone is implicated in the etiology of breast cancer. Progesterone is an activator of Progesterone Receptor. It is a C-21 steroid hormone.

Reference

1: Gee RE, Kuy S, Karas LO. Progesterone for Prevention of Preterm Birth:
Shortcomings and Unintended Consequences of the Orphan Drug Act. Obstet Gynecol.
2017 Nov 3. doi: 10.1097/AOG.0000000000002308. [Epub ahead of print] PubMed PMID:
29112651.

2: Caufriez A, Leproult R, Copinschi G. Circadian profiles of progesterone,
gonadotropins, cortisol and corticotropin in cycling and postmenopausal women.
Chronobiol Int. 2017 Nov 7:1-8. doi: 10.1080/07420528.2017.1381971. [Epub ahead
of print] PubMed PMID: 29111782.

3: Balassa T, Berta G, Jakab L, Bohonyi N, Szekeres-Bartho J. The effect of the
Progesterone-Induced Blocking Factor (PIBF) on E-cadherin expression, cell
motility and invasion of primary tumour cell lines. J Reprod Immunol. 2017 Nov
2;125:8-15. doi: 10.1016/j.jri.2017.10.047. [Epub ahead of print] PubMed PMID:
29107859.

4: Schwarz TI, Katsiadaki I, Maskrey BH, Scott AP. Uptake and metabolism of
water-borne progesterone by the mussel, Mytilus spp. (Mollusca). J Steroid
Biochem Mol Biol. 2017 Oct 26. pii: S0960-0760(17)30302-3. doi:
10.1016/j.jsbmb.2017.10.016. [Epub ahead of print] PubMed PMID: 29107179.

5: Shorten PR, Ledgard AM, Donnison M, Pfeffer PL, McDonald RM, Berg DK. A
mathematical model of the interaction between bovine blastocyst developmental
stage and progesterone-stimulated uterine factors on differential embryonic
development observed on Day 15 of gestation. J Dairy Sci. 2017 Nov 2. pii:
S0022-0302(17)30987-6. doi: 10.3168/jds.2017-12845. [Epub ahead of print] PubMed
PMID: 29103729.

6: Wilsterman K, Pepper A, Bentley GE. Low glucose availability stimulates
progesterone production by mouse ovaries in vitro. J Exp Biol. 2017 Nov 2. pii:
jeb.164384. doi: 10.1242/jeb.164384. [Epub ahead of print] PubMed PMID: 29097592.

7: Turan N, Miller BA, Huie JR, Heider RA, Wang J, Wali B, Yousuf S, Ferguson AR,
Sayeed I, Stein DG, Pradilla G. Effect of Progesterone on Cerebral Vasospasm and
Neurobehavioral Outcomes In A Rodent Model of Subarachnoid Hemorrhage. World
Neurosurg. 2017 Oct 30. pii: S1878-8750(17)31846-6. doi:
10.1016/j.wneu.2017.10.118. [Epub ahead of print] PubMed PMID: 29097330.

8: Lundgren JA, Kim SH, Burt Solorzano CM, McCartney CR, Marshall JC.
Progesterone Suppression of LH Pulse Frequency in Adolescent Girls with
Hyperandrogenism: Effects of Metformin. J Clin Endocrinol Metab. 2017 Oct 31.
doi: 10.1210/jc.2017-02068. [Epub ahead of print] PubMed PMID: 29095983.

9: Livergood MC, Trudell A. Risk of Preterm Birth with Vaginal Progesterone in
Twin Pregnancies. Am Fam Physician. 2017 Nov 1;96(9):Online. PubMed PMID:
29094879.

10: Mori S, Takagaki R, Fujii S, Urushibara K, Tanatani A, Kagechika H. Novel
Non-steroidal Progesterone Receptor Ligands Based on m-Carborane Containing a
Secondary Alcohol: Effect of Chirality on Ligand Activity. Chem Pharm Bull
(Tokyo). 2017;65(11):1051-1057. doi: 10.1248/cpb.c17-00544. PubMed PMID:
29093292.