Prochlorperazine Dimaleate

• CAT Number: A000059
• CAS Number: 84-02-6
• Molecular Formula: C28H32ClN3O8S
• Molecular Weight: 606.087
• Purity: ≥95%
• Target: Dopamine (D2) Receptor Antagonist
• Storage: Store at -20°C
• IUPAC Name: (Z)-but-2-enedioic acid;2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
• InChI: InChI=1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
• InChIKey: DSKIOWHQLUWFLG-SPIKMXEPSA-N
• SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly potent typical antipsychotic, 10–20 times more potent than chlorpromazine. Prochlorperazine dimaleate is also used to treat migraine headaches.

Reference

1:Fertil Steril. 1976 Sep;27(9):1009-23. Evaluation of intramuscular 15(s)-15-methyl prostaglandin F2 alpha tromethamine salt for induction of abortion, medications to attenuate side effects, and intracervical laminaria tents.Gruber W,Brenner WE,Staurovsky LG,Dingfelder JR,Wells JS, PMID: 964392
2: JACOBZINER H, RAYBIN HW. Prochlorperazine dimaleate poisoning. N Y State J
Med. 1962 Dec 1;62:3804-6. PubMed PMID: 13964382.