Probenecid

• CAT Number: A000386
• CAS Number: 57-66-9
• Molecular Formula: C13H19NO4S
• Molecular Weight: 285.4
• Purity: ≥95%
• Storage: -20°C
• InChI: 1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
• InChIKey: DBABZHXKTCFAPX-UHFFFAOYSA-N
• SMILES: CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O

Probenecid is an inhibitor of MRP1. This compound blocks the active site of MRP1 and prevents cellular efflux of other active compounds, enhancing their effectiveness by allowing them to remain in the cytoplasm. Probenecid is an inhibitor of Pannexin-1. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

Reference

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